Prof. Bik-Kwoon Tye and Prof. Danny Leung, in collaboration with the University of Hong Kong (HKU), recently made a breakthrough on how the ORC selects the site for origins of replications and the basis behind the divergence between humans and yeast.
Using zebrafish as an animal model, Prof. Zilong Wen and his research team identified two distinct microglial populations – the phagocytotic microglia and regulatory microglia. Their findings were published in the journal Science Advances.
In this study published in the journal PNAS, Prof. Tom Cheung and his research team have found that a lncRNA, LncMyoD, regulates the differentiation of muscle cells through modulating chromatin accessibility.
Prof. Yusong Guo and his collaborators, Prof. Liwen Jiang at the Chinese University of Hong Kong and Prof. Yan Yan at LIFS of HKUST, have discovered a novel molecular mechanism that controls the delivery of a key protein in PCP. Their findings, published in the Journal of Biological Chemistry, can provide useful guidance on the development of new drugs for cancer treatment.
A research team led by Prof. Tuan Anh NGUYEN, Assistant Professor in the Division of Life Science at HKUST, recently discovered how RNA elements in the upper stem of pri-mRNAs affect the action of Microprocessor.
Prof. Mingjie Zhang published in Cell Reports that a point mutation of Myo7a (Myosin VIIa) found in Usher syndrome patients leads to disruption of the hair cell tip-link protein complex formation through liquid-liquid phase separation.
Prof. Mingjie Zhang and his collaborators decoded the binding mechanisms governing the WW domain tandem-containing proteins. Their findings, published in eLife, reveal the recognition mechanisms of tandem WW domains with their peptide ligands which can serve as a guiding tool for functional studies of WW domain-containing proteins in the future.