MORE ABOUT HKUST
University News
Academic Departments A-Z
Life@HKUST
Library
Map & Directions
Jobs@HKUST
Faculty Profiles
About HKUST

Search

More About HKUST
Home Why LIFS? Careers Contact Us
HKUST HKUST Division of Life Science
Research
FacultyResearch AreasFacilities
Education
Undergraduate
ProgramsScholarshipsCurriculumAdmissionCoursesResearch ProjectsInternshipsUndergraduate Advising TeamArticulation Pathways
Postgraduate
MPhil/PhD in Life SciencePhD Dual-degree ProgrammeMSc in BiotechnologyAdmissionCoursesSummer Camp
QA at HKUST
News & Events
NewsEvents
Home
October 19, 2018 by rickie News 0 comments

The Wang Genomic Laboratory has uncovered the first comprehensive mutational landscape of secondary glioblastoma and identified an actionable mutation for precision cancer treatment

Quanhua Mu, Yiyun Chen, Biaobin Jiang, and Yoonhee Nam from Prof. Jiguang Wang’s lab have integrated sequencing data from not only the public literature but also a number of newly collected cases by Dr. Tao Jiang’s team from Beijing Neurosurgical Institute and Beijing Tiantan Hospital, and uncovered the mutational landscape of secondary glioblastoma (sGBM) in East Asian cohort. This systematic study reveals genomic differences among low-grade glioma, primary glioblastoma and sGBM. Strikingly, their study discovered that genomic mutations that lead to METex14 are highly enriched in sGBM cases, and the presence of METex14 transcripts is an important biomarker that predicts significantly worse patient survival. More importantly, MET protein is an actionable drug target, which has been verified in a MET-targeted Phase I clinical trial led by our collaborator at Beijing Tiantan Hospital. Out of the six sGBM patients who completed the trial, two achieved the partial response, two achieved stable disease, and two have progressed disease. This encouraging result highlights the great potential of precision cancer medicine in treating previous incurable cancers by tailoring particular therapies according to personalized genomic information.
Click here to read the Full article from Cell journal.
Click here to know more about The Wang Genomic Laboratory.
3

Related Posts

Two LIFS distinguished scholars receiving Croucher Innovation Awards and Senior Research Fellowship

December 12, 2018
Read More

The Annual Scientific Image Competition 2021: Winners Announced!

December 14, 2021
Read More

School of Science Teaching, Research and Service Award 2018 recipients announced

December 4, 2018
Read More

Mr. Simon Wong Donating HK$182K to LIFS

January 18, 2021
Read More

Prof. Zhang’s research team made a ground-breaking discovery on postsynaptic density formation.Previous Post
Best teaching assistant award 2017/18Next Post

ADDRESS

Division of Life Science
The Hong Kong University of Science and Technology
Clear Water Bay
Kowloon, Hong Kong

PHONE

Facsimile No. :
(852) 2358 1552

Telephone No. :
(852) 2358-7272 / 7339
  • Home
  • Careers
  • Contact us
  • Faculty
  • Intranet
HKUST
PrivacySitemap
Copyright © The Hong Kong University of Science and Technology.All rights reserved.
Follow HKUST on
FacebookInstagramLinkedinYouTube
PrivacySitemap