Professor Shangyu Dang completed his undergraduate studies at Tsinghua University, where he worked in the lab of Professor Nieng Yan. During this time, he utilized X-ray crystallography to unravel the working mechanism of a fucose transporter (FucP). Following his Bachelor of Science degree, he pursued his Ph.D. in the lab of Professor Yigong Shi, also at Tsinghua University. His research focused on the structure and function of the presenilin homologue (PSH), which provided valuable insights into gamma-secretase and Alzheimer’s disease. After earning his Ph.D. from Tsinghua University in 2014, Prof. Dang joined the University of California San Francisco (UCSF) as a postdoctoral researcher. He worked in the lab of Professor Yifan Cheng, supported by a Human Frontier Science Program (HFSP) Long-term fellowship. During his postdoc training, he received comprehensive training in cryo-electron microscopy (cryo-EM) and successfully determined the structures of several membrane proteins, including TMEM16 and TRP family proteins, using the single-particle cryo-EM technique. Currently, Professor Shangyu Dang holds the position of Assistant Professor in the Division of Life Science at the Hong Kong University of Science and Technology (HKUST).