Research Question

Molecular regulation of muscle stem cells, myogenic differentiation, and muscle regeneration.

Representative Publications

1. An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang HT, and Wu Z (2017). A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. Dev Cell. 41: 382-91.
2. Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung TH, Liu K, and Wu Z (2018). p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells. EMBO J. e98239.
3. Zhou S, Han L, Weng M, Zhu H, Heng Y, Wang G, Shen Z, Chen X, Fu X, Zhang M, and Wu Z (2021). Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. Proc Natl Acad Sci U S A. 118: e2021093118.
4. Han L, Wang G, Zhou S, Situ C, He Z, Li Y, Qiu Y, Huang Y, Xu A, Ong MTY, Wang H, Zhang J, Wu Z. (2022). Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. Cell Rep. 39: 110884.
5. Han L, Qiu Y, He L, Gao C, Zhou N, Fu X, Xu J, Lin L, Wang H, Biswal S, and Wu Z (2025). Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells. Nat Commun 16:10505. (doi: 10.1038/s41467-025-65506-4)