Dinoflagellates have some of the largest reported genome sizes organized in the third chromosome architectures. Being the major phytoplankton group with cellulosic cell wall that are deposited subcellularly. Cellular growth is not hindered with apolar orientation (e.g. budding) no partial nuclear envelope breakdown.
Cellulosic thecal plate formation, liquid crystalline chromosome dynamics and apolar subcellular growth, the three focuses of the laboratory, encompass carbon fixation, cellulose biogenesis, vesicular transport rate, quantitative Ca2+-membrane interactomes, optical biology, photobiology, and spatial-temporal volume depletion force axis, in addition to dinoflagellate track records in circadian rhythm, peridinin photobiology, DNA-omega-3 enrichment and toxin biosynthesis; their developments with the ongoing genetic dissection and genome annotations will put these focuses at cross-forefronts between physical biology, biochemistry, synthetic biology, and molecular biology. Research Interest.
Being a key phytoplankton group, the major harmful algal bloom agents, and the zooxanthellae that was deceased in coral bleaching, the dinoflagellates have made their footprints on Earth. Coral reef ecosystems, including those of the disappearing Great Barrier Reef, depend on symbiotic dinoflagellates for their primary productivity
Having almost died, and recovered, from liver failure attributed to a severe Hepatitis A infection in 2016, I am more resolved in focusing on my research interests; my laboratory accept diversity of experiences.
Candidates with trainings in physical biology molecular cell biology fields are especially welcome. Potential students are encouraged to apply directly through the university system. Prof. Joseph Wong Biosketch9
Kwok, A.C.M., Zhang, F., Ma, Z., Chan, W.S., Yu, V.C., Tsang, J.S.H. and Wong, J.T.Y. (2020) Functional responses between PMP3 small membrane proteins and membrane potential. Environmental Microbiology
Kwok A.C. M., C., Lam, W.T. and Wong J.T.Y. (2022) Responses of Dinoflagellate Cells to Ultraviolet-C Irradiation. Environmental Microbiology.
Chan, W.S., Kwok, A.C.M., and Wong, J.T.Y. (2019) Knockdown of dinoflagellate cellulose synthase CesA1 resulted in malformed intracellular cellulosic thecal plates and severely impeded cyst-to-swarmer transition. Frontiers in Microbiology3389/fmicb.2019.00546
Wong JTY (2019) Architectural organization of dinoflagellate liquid crystalline chromosomes. Microorganism7: 27 doi:10.3390/microorganisms7020027
Kwok A.C. M. and Wong J.T.Y. (2010) Activities of a walled-bound cellulase is coupled to and is required for cell cycle progression in a dinoflagellate. Plant Cell 22:1281-1298. http://www.plantcell.org/content/22/4/1281
Chan Y.H. and Wong J.T.Y. (2007) Concentration-dependent organization of DNA by the dinoflagellate histone-like protein HCc3. Nucleic Acids Research; 35:2573-2583. DOI: 10.1093/nar/gkm165Wong J.T.Y. (2007) Concentration-dependent organization of DNA by the dinoflagellate histone-like protein HCc3. Nucleic Acids Research; 35:2573-2583. DOI: 10.1093/nar/gkm165