Professor Li-Sheng Zhang earned his Ph.D. in 2019 from The University of Chicago in Professor Chuan He lab, with the award of HHMI International Student Research Fellowship. During Ph.D. training, Li-Sheng discovered ALKBH7-mediated reversible RNA methylation in mitochondrial polycistronic RNA and demonstrated mRNA internal N7-methylguanosines via base-resolution sequencing. Li-Sheng continued working as a postdoctoral scholar in Professor Chuan He lab upon the completion of his Ph.D., where he further expanded the quantitative base-resolution sequencing strategy to investigate diverse RNA modifications in mammals, including BID-seq for pseudouridine, Nm-Mut-seq for 2′-O-methylation (Nm), DAMM-seq for m1A/m3C/m1G/m22G, m7G-seq/m7G-quant-seq for internal m7G, etc. Li-Sheng works on chemical biology, epigenetics, RNA biology, and bioinformatics.