Biophysics, NMR Spectroscopy, Structural Biology. Areas of focus:
Biological NMR of nucleic acids, proteins, and their complexes with ligand molecules.
Development of multidimensional NMR spectroscopic methods for structure-function studies of biomolecules.
Structure-functional study of proteins in human DNA replication.
Lead compound screening and design by NMR.
Changdong Liu, Bo Zhou, Yanyan Geng, Dick Yan Tam, Rui Feng, Haitao Miao, Naining Xu, Xiao Shi, Yingying You, Yuning Hong, Ben Zhong Tang,d Pik Kwan Lo, Vitaly Kuryavyi* and Guang Zhu* (2019)A Chair-type G-quadruplex Structure Formed by a Human Telomeric Variant DNA in K+ solution. Chemical Science, 10, 218 – 226, DOI: 10.1039/C8SC03813A
Yanyan Geng, Changdong Liu, Bo Zhou, Qixu Cai, Haitao Miao, Xiao Shi and Guang Zhu* (2019) The Crystal Structure of an Antiparallel Chair-type G-quadruplex Formed by Bromo-substituted Human Telomeric DNA. Nucleic Acids Research in press
Bo Zhou, Yanyan Geng, Changdong Liu, Haitao Miao, Yaguang Ren, Naining Xu, Xiao Shi, Yingying You, Tunglun Lee, and Guang Zhu* (2018) Characterization of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence. Sci. Rep. 8:2366.
Bo Zhou, Changdong Liu, Zhiwen Xu, and Guang Zhu* (2012) Structural basis for homeodomain recognition by the cell cycle regulator Geminin, Proc. Natl. Acad. Sci. U S A. 109 23 8931-8936
Changdong Liu, Rentian Wu, Bo Zhou, Jiafeng Wang, Bik Tye, Chun Liang* and Guang Zhu* (2012) Structural Insights into the Cdt1-Mediated Mcm2-7 Chromatin Loading. Nucleic Acids Res. 40, 3208-17.