Biophysics, NMR Spectroscopy, Structural Biology. Areas of focus:
Biological NMR of nucleic acids, proteins, and their complexes with ligand molecules.
Development of multidimensional NMR spectroscopic methods for structure-function studies of biomolecules.
Structure-functional study of proteins in human DNA replication.
Lead compound screening and design by NMR.
Yanyan Geng, Changdong Liu, Qixu Cai, Zhipu Luo, Haitao Miao, Xiao Shi, Naining Xu, Chun Po Fung, To To Choy, Bing Yan, Ning Li, Peiyuan Qian*, Bo Zhou* and Guang Zhu* (2021) Crystal structure of parallel G-quadruplex formed by the two-repeat ALS and FTD related GGGGCC sequence, Nucleic Acid Research, 49(10), pp. 5881-5890
Naining Xu, Yingying You, Changdong Liu, Maxim Balasov, Lee Tung Lun, Yanyan Geng, Chun Po Fung, Haitao Miao, Honglei Tian, To To Choy, Xiao Shi, Zhuming Fan, Bo Zhou, Katarina Akhmetova, Hongyu Yang, Quan Hao, Peiyuan Qian, Igor Chesnokov*, and Guang Zhu* (2020) Structural Basis of DNA Replication Origin Recognition by Human Orc6 Protein Binding with DNA, Nucleic Acid Research; 48(19):11146-11161.
Yanyan Geng, Changdong Liu, Bo Zhou, Qixu Cai, Haitao Miao, Xiao Shi and Guang Zhu* (2019) The Crystal Structure of an Antiparallel Chair-type G-quadruplex Formed by Bromo-substituted Human Telomeric DNA. Nucleic Acids Research, 47, 10, 04, 5395–5404,
Changdong Liu, Bo Zhou,ab Yanyan Geng, Dick Yan Tam, Rui Feng, Haitao Miao, Naining Xu, Xiao Shi, Yingying You, Yuning Hong,d Ben Zhong Tang,d Pik Kwan Lo, Vitaly Kuryavyi and Guang Zhu*(2019) A Chair-type G-quadruplex Structure Formed by a Human Telomeric Variant DNA in K+ solution. Chemical Science, 10, 218 – 226
Bo Zhou, Changdong Liu, Zhiwen Xu, and Guang Zhu* (2012) Structural basis for homeodomain recognition by the cell cycle regulator Geminin, Proc. Natl. Acad. Sci. U S A. 109 23 8931-8936