Biophysics, NMR Spectroscopy, Structural Biology. Areas of focus:
Biological NMR of nucleic acids, proteins, and their complexes with ligand molecules.
Development of multidimensional NMR spectroscopic methods for structure-function studies of biomolecules.
Structure-functional study of proteins in human DNA replication.
Lead compound screening and design by NMR.
Biophysics.
Representative Publications
Wenkang Ye, Xinnan Wang, Parvej Alam, Changdong Liu, Monica,C. Suen, Jianwei Tang , Herman H.Y. Sung , Ian D. Williams , Eric Y. Yu , Jacky W.Y. Lam , Guang Zhu*, Ben-Zhong Tang* , Pei-Yuan Qian* (2024) Discovery of a novel marine bacterial AIEgen that lights up specific G-quadruplexes, Chemical Engineering Journal,v497, 154947
Yanyan Geng, Changdong Liu, Monica Ching Suen, Maitao Miao, Naining Xu, Yuanyuan Xie, Bingchang Zhang, Xueqin Chen, Zhanxiang Wang, Yuanjian Song, Qixu Cai*, Guang Zhu*(2024) Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD. Nucleic Acids Research , 52 , 7961–7970
Aifang Cheng, Changdong Liu, Wenkang Ye, Duli Huang, Weiyi She, Xin Liu, Chun Po Fung, Naining Xu, Monica Ching Suen, Wei Ye, Herman Ho Yung Sung, Ian Duncan Williams, Guang Zhu*and Pei-Yuan Qian* (2022) Selective C9orf72 G-Quadruplex-Binding Small Molecules Ameliorate Pathological Signatures of ALS/FTD Models, Med. Chem. 2022, 65, 19, 12825–12837, doi.org/10.1021/acs.jmedchem.2c00654 (cover page)
Yanyan Geng, Changdong Liu, Qixu Cai, Zhipu Luo, Haitao Miao, Xiao Shi, Naining Xu, Chun Po Fung, To To Choy, Bing Yan, Ning Li, Peiyuan Qian*, Bo Zhou* and Guang Zhu*(2021) Crystal structure of parallel G-quadruplex formed by the two-repeat ALS and FTD related GGGGCC sequence, Nucleic Acids Research, 49(10), pp. 5881-5890 https://doi.org/10.1093/nar/gkab302
Naining Xu, Yingying You, Changdong Liu, Maxim Balasov, Lee Tung Lun, Yanyan Geng, Chun Po Fung, Haitao Miao, Honglei Tian, To To Choy, Xiao Shi, Zhuming Fan, Bo Zhou, Katarina Akhmetova, Hongyu Yang, Quan Hao, Peiyuan Qian, Igor Chesnokov*, and Guang Zhu*(2020) Structural Basis of DNA Replication Origin Recognition by Human Orc6 Protein Binding with DNA, Nucleic Acids Research, Nov 4;48(19):11146-11161. doi: 10.1093/nar/gkaa751.
