Research Questions

Mechanism and cell cycle control of DNA replication in the budding yeast Saccharomyces cerevisiae; regulation of DNA replication in normal and cancer cells; molecular cancer detection and anticancer drugs.

Representative Publications

1. Amin A., Wu R., Cheung M.H., Scott J.F., Wang Z., Zhou Z., Liu C., Zhu G., Wong C.K.C., Yu Z^*. and Liang C*^#. (2020) An essential and cell cycle-dependent ORC dimerization cycle regulates eukaryotic chromosomal DNA replication. Cell Reports 30, 3323–3338. (^#main contact author)
2. Cheung M.H., Amin A., Wu R., Qin Y., Zou L., Yu Z., and *Liang C. (2019) Human NOC3 Is Essential for DNA Replication Licensing in Human Cells. Cell Cycle 18, 605-620.
3. Huang Y, Amin A., Qin Y., Wang Z., Jiang H., Liang L., Shi L., *Liang C. (2016) A Role of hIPI3 in DNA Replication Licensing in Human Cells. PLoS One 11(4):e0151803.
4. Feng, D.R., Tu Z., Wu, W.Y., and *Liang, C. (2003) Inhibiting the Expression of DNA Replication-Initiation Proteins Induces Apoptosis in Human Cancer Cells. Cancer Res. 63: 7356-7364.
5. *Liang, C. (2002) Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell, 109, 849-860.