Prof. Mingjie Zhang and his team reported that stargazin uses its entire C-terminal tail bind PSD-95 via a specific and multivalent interaction mode. Their findings, published in Neuron, reveal the mechanism of AMPA receptor synaptic trafficking and transmission at the neuronal synapses.
Prof. Mingjie Zhang has just won a highly competitive three-year grant from the Human Frontiers in Science Program (HFSP) to investigate the molecular mechanism by which calcium ion determines AMPA receptor trafficking and retention at the neuronal synapse.
Prof. Mingjie Zhang and his research team published a paper in the journal Cell, titled “Reconstituted postsynaptic density as a molecular platform for understanding synapse formation and plasticity”. This paper has recently been selected as one of the “Best Of Cell 2018” research article collections to showcase this past year’s most exciting cell biology research.