Dr. Yan received a B.S. degree in Peking University in 2004 and a Ph.D. degree in Molecular Biology from Princeton University in 2010.

Research Question

Our laboratory is interested in using quantitative approaches to understand how cell structural components are orchestrated to regulate tissue morphogenesis and growth.

Representative Publications

1. Mingxi Deng, Ying Wang, Lina Zhang, Yang Yang, Shengshuo Huang, Jiguang Wang, Hao Ge, Toyotaka Ishibashi, Yan Yan, Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs, Development 2019 : dev.179754 doi: 10.1242/dev.179754,
2. Tiantian Ji*, Lina Zhang*, Mingxi Deng, Shengshuo Huang, Ying Wang, Tri Thanh Pham, Andrew Alan Smith, Varun Sridhar, Clemens Cabernard, Jiguang Wang, Yan Yan, Dynamic MAPK signaling activity underlies a transition from growth arrest to proliferation in Drosophila scribble mutant tumors. Disease Models & Mechanisms. 2019 Aug 1. pii: dmm.040147. doi: 10.1242/dmm.040147.
3. Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts, Yanru An, Guosheng Xue, Yang Shaobo, Deng Mingxi, Xiaowei Zhou, Weichuan Yu, Toyotaka Ishibashi, Lei Zhang, Yan Yan, Development, 2017 June, Highlighted in Editor’s Choice, “A new model for single-cell delamination”
4. Kenneth Kin Lam Wong, Wenyang Li, Yanru An, Yangyang Duan, Yibin Kang, Yan Yan, β-Spectrin regulates the Hippo signaling pathway and modulates the basal actin network, J Biol Chem, 2015 Mar.
5. Yan Yan*, Natalie Denef*, Trudi Schupbach, The vacuolar proton pump, V-ATPase, is required for Notch signaling and endosomal trafficking in Drosophila. Dev Cell. 2009 Sep *These authors contribute equally to this work.

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