Prof. Yusong Guo and his collaborators, Prof. Liwen Jiang at the Chinese University of Hong Kong and Prof. Yan Yan at LIFS of HKUST, have discovered a novel molecular mechanism that controls the delivery of a key protein in PCP. Their findings, published in the Journal of Biological Chemistry, can provide useful guidance on the development of new drugs for cancer treatment.
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A research team led by Prof. Tuan Anh NGUYEN, Assistant Professor in the Division of Life Science at HKUST, recently discovered how RNA elements in the upper stem of pri-mRNAs affect the action of Microprocessor.
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Prof. Mingjie Zhang published in Cell Reports that a point mutation of Myo7a (Myosin VIIa) found in Usher syndrome patients leads to disruption of the hair cell tip-link protein complex formation through liquid-liquid phase separation.
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Prof. Mingjie Zhang and his collaborators decoded the binding mechanisms governing the WW domain tandem-containing proteins. Their findings, published in eLife, reveal the recognition mechanisms of tandem WW domains with their peptide ligands which can serve as a guiding tool for functional studies of WW domain-containing proteins in the future.
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Prof. Mingjie Zhang and his team reported that stargazin uses its entire C-terminal tail bind PSD-95 via a specific and multivalent interaction mode. Their findings, published in Neuron, reveal the mechanism of AMPA receptor synaptic trafficking and transmission at the neuronal synapses.
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Prof. Mingjie Zhang and his collaborators Prof. Ming from the University of Pennsylvania reported a DISC1 and ATF4 interaction in iPSC-derived neurons with a DISC1 mutation. Their findings, published in Molecular Psychiatry, reveal the underlying mechanisms linking the genetic lesion and functional phenotypes of psychiatric disorders.
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Prof. Yusong Guo and his collaborators reported that the endoplasmic reticulum fusogen atlastin was involved in regulating cargo mobility and COPII formation in the ER. Their finding, published in PNAS on June 25, provides important insight into the physiological role of the tubular ER network.
Read MoreProf. Mingjie Zhang has just won a highly competitive three-year grant from the Human Frontiers in Science Program (HFSP) to investigate the molecular mechanism by which calcium ion determines AMPA receptor trafficking and retention at the neuronal synapse.
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aTyr Pharma, Inc., a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel immunological pathways, recognized the collaboration between its Hong Kong subsidiary, Pangu BioPharma (Pangu), and HKUST for contributions leading to the discovery of ATYR1923, which is currently being evaluated in patients with pulmonary sarcoidosis.
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